Nigrovic Headshot 2016 12 Final

Director: Peter A. Nigrovic, M.D.

Harvard Catalyst Profile

BRI Profile

Dr. Nigrovic is an adult and pediatric rheumatologist at the Brigham and Women’s Hospital and Boston Children’s Hospital, directing arthritis biorepositories at both institutions. He founded and directs the Center for Adults with Pediatric Rheumatic Illness (CAPRI) at the Brigham and Women’s Hospital.  He is an Associate Professor of Medicine at Harvard Medical School.  Dr. Nigrovic serves on the editorial board of Arthritis & Rheumatology and on the Steering Committee of the US/Canadian pediatric research collaborative CARRA (the Childhood Arthritis & Rheumatology Research Alliance), as well as on the scientific advisory boards of the Rheumatology Research Foundation and the Arthritis National Research Foundation. He is the founding co-chair of AMIGO, the American College of Rheumatology’s inter-institutional mentoring program in pediatric rheumatology.  Dr.  Nigrovic’s research focuses on understanding mechanisms of inflammatory arthritis, using both human samples and mouse models.

Dr. Nigrovic received his Bachelor’s of Arts from Amherst College and his medical degree at Harvard Medical School.  He completed med/peds residency in the Harvard combined program and med/peds rheumatology fellowship at Boston Children’s Hospital and the Brigham and Women’s Hospital.

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Associate Director: Elizabeth Karlson, M.D.

Harvard Catalyst Profile

BRI Profile

Dr. Karlson is a rheumatologist and epidemiologist at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School. She is director of the rheumatic disease epidemiology research program for the Section of Clinical Sciences, serves as a co-Director for the Human Immunology Center and also co-founded and co-directs the Partners Healthcare Biobank.

Dr. Karlson received her Bachelor’s of Arts from Brown University and her medical degree at Johns Hopkins Medical School.  She completed her internal medicine and rheumatology training at Brigham and Women’s Hospital.

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Chair of JBC Executive Committee: Michael B. Brenner, M.D.

Harvard Catalyst Profile

BRI Profile

Dr. Michael Brenner is the Chief of the Division of Rheumatology, Immunology, and Allergy at the Brigham and Women’s Hospital and the Theodore B. Bayles Professor of Medicine at Harvard Medical School.  He is a member of the US National Academy of Science.  Dr. Brenner’s research has made a number of significant discoveries in the fields of antigen presentation as well as autoimmune diseases such as rheumatoid arthritis.

Dr. Brenner received his Bachelor’s of Science from Washington University in St. Louis and his medical degree at Vanderbilt University School of Medicine.  He completed his residency in internal medicine at Vanderbuilt University Hospital and his fellowship in Rheumatology at University of California.

Project Manager: Minah Iqbal, M.A.

Minah serves as a project manager for the Joint Biology Consortium.  She has research experience in various fields which include neurology, obesity, oncology and genetics.  She received her Bachelor’s of Science from Simmons College and her Master’s in Biotechnology from Columbia University.

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Chair: Ellen Gravallese M.D

Dr. Gravallese is the Myles J. McDonough Chair in Rheumatology, Professor of Medicine and Cell and Developmental Biology and Chief of the Division of Rheumatology at the University of Massachusetts. Dr. Gravallese is board certified in both rheumatology and pathology and is an internationally-renowned expert on the effects of inflammation on bone in rheumatic diseases. Her laboratory played a pivotal role in identifying the contribution of RANK/RANKL interactions in osteoclast-mediated joint injury in murine and human systems, among other contributions.

Dr. Gravallese received her Bachelor of Arts degree from Harvard College and her medical degree from Columbia College of Physicians & Surgeons. She completed a joint residency in internal medicine and pathology, followed by rheumatology fellowship training at Brigham and Women’s Hospital and a postdoctoral research fellowship in immunology with Dr. Laurie Glimcher.

Solomon

JBC member: Daniel H. Solomon, M.D., M.P.H.

Harvard Catalyst Profile

BRI Profile

Dr. Solomon is Chief of the Section of Clinical Sciences in the Division of Rheumatology, Immunology and Allergy and Matthew H. Liang Distinguished Chair in Arthritis and Population Health at BWH and Professor of Medicine at Harvard Medical School,. He has extensive experience in the conduct of clinical and translational research, is a co-investigator of BRASS as well as other RA registries, such as CORRONA and is a senior mentor of multiple junior and established investigators.

Dr. Solomon received his Bachelor’s of Arts and medical degree from Yale.  He received his Master’s in Public Health from Harvard School of Public Health.  Dr. Solomon completed his residency and fellowship at Brigham and Women’s Hospital.

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JBC member: Nancy Shadick, M.D., M.P.H.

Harvard Catalyst Profile

BRI Profile

Dr. Shadick is the Director of Translational Research Development in the Division of Rheumatology, Immunology and Allergy and is the founder and principal investigator of the BRASS study, one of the largest single center cohorts of RA in the nation.  She is a clinical researcher and epidemiologist with numerous publications in RA clinical and genetics outcomes as well as other rheumatic diseases.

Dr. Shadick received her A.B. from Barnard College and her medical degree at New York University.  She completed her residency at Columbia-Presbyterian Hospital and her fellowship at Brigham and Women’s Hospital.  She completed her Master’s in Public Health from Harvard School of Public Health.

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JBC member: Deepak Rao, M.D., Ph.D.

Harvard Catalyst Profile

Deepak Rao MD PhD is a junior faculty member of the Division of Rheumatology, Immunology, Allergy at BWH and co-Director of the BWH Human Immunology Center. His work focuses on high-dimensional and functional analyses of T cells in blood and tissue samples from patients with RA, SLE, GCA and other rheumatic diseases. He coordinates the PROSET-HD study and is integrally involved in translational research across BWH and BCH. He previously received the 2014 American College of Rheumatology Distinguished Fellow Award and the 2016 Tobe and Stephen E. Malawista Endowment from the Rheumatology Research Foundation.

Clark

JBC member: Rachael Clark, M.D., Ph.D.

Harvard Catalyst Profile

BRI Profile

Dr. Clark is an Associate Physician at Brigham and Women’s Hospital and Associate Professor of Dermatology at Harvard Medical School.

Dr. Clark received her Bachelor’s of Science from California Institute of Technology and her medical as well as doctoral degrees from Harvard Medical School.  She completed her combined dermatology residency at Brigham and Women’s Hospital, Beth-Israel Deaconess Medical Center, and Massachusetts General Hospital.

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Director: Elizabeth Karlson, M.D.

Harvard Catalyst Profile

BRI Profile

Dr. Karlson is a rheumatologist and epidemiologist at Brigham and Women’s Hospital and Professor of Medicine at Harvard Medical School. She is director of the rheumatic disease epidemiology research program for the Section of Clinical Sciences, serves as a co-Director for the Human Immunology Center and also co-founded and co-directs the Partners Healthcare Biobank.

Dr. Karlson received her Bachelor’s of Arts from Brown University and her medical degree at Johns Hopkins Medical School.  She completed her internal medicine and rheumatology training at Brigham and Women’s Hospital.

Associate Director: Jeffrey A. Sparks, M.D., M.M.Sc.

Harvard Catalyst Profile

BRI Profile

Dr. Sparks is an Assistant Professor of Medicine at Harvard Medical School and a clinical researcher and rheumatologist at Brigham and Women’s Hospital.  Dr. Sparks is a population scientist with an overall focus on using patient-oriented and epidemiologic research studies to evaluate the etiology, outcomes, and public health burden of rheumatic diseases such as rheumatoid arthritis (RA). He performs studies to evaluate the genetic, environmental, serologic, and familial risk factors for RA, clinical trials for RA prevention, RA outcomes research focusing on the respiratory burden of RA, and evaluates metabolic factors such as weight loss for RA outcomes.

He is the chair of the Early Investigator Subcommittee of the American College of Rheumatology and has an interest in facilitating the development of mentorship within rheumatology. He has received awards from the American College of Rheumatology, Rheumatology Research Foundation, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

Dr. Sparks received his Bachelor’s of Science in physics from the University of Arkansas and medical degree from the University of Arkansas for Medical Sciences. He completed his Master’s of Medical Sciences degree in translational and patient-oriented research at Harvard Medical School.  Dr. Sparks completed his residency in internal medicine at Washington University in St. Louis and his fellowship in rheumatology at Brigham and Women’s Hospital.

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Associate Director: Lauren Henderson, M.D., M.M.Sc.

Harvard Catalyst Profile

Dr. Henderson is an Attending Physician in Rheumatology at Boston Children’s Hospital and an Instructor in Pediatrics at Harvard Medical School.  She oversees the daily operations of the New-onset JIA Registry and the Rheumatic Diseases of Childhood Biorepository at Boston Children’s Hospital. In addition, she serves as the subcommittee chair for the CARRA ( (Childhood Arthritis and Rheumatology Research Alliance) –  federated biorepository that includes more  than 60 pediatric rheumatology sites in the US and Canada.

Dr. Henderson received her Bachelor’s of Arts from Cornell University and her medical and Master’s degrees from Harvard Medical School.  She completed her pediatrics and rheumatology training at Boston Children’s Hospital.  Her research focuses on the role of regulatory T cells in the pathogenesis of juvenile idiopathic arthritis.

Lederer

Director: James Lederer, Ph.D.

Harvard Catalyst Profile

BRI Profile

Dr. Lederer is Associate Professor of Surgery at Harvard Medical School and Brigham and Women’s Hospital, where his studies have focused on the immunology of trauma and shock in both mice and humans. He is founder and director of the Harvard Medical Area CyTOF Consortium, with particular expertise in the processing and analysis of joint tissues as director of CyTOF for the NIH’s Accelerated Medicines Partnership (AMP) in arthritis research. In particular, he developed and validated much of the cell processing methods for blood and tissue cells to be used for the AMP research program.

Dr. Lederer received his B.Sc, M.D. and Ph.D. at University of Wisconsin-Madison and he completed his research fellowship at Brigham and Women’s Hospital.

Chad Nusbaum

Associate Director: Chad Nusbaum, Ph.D.

Broad Institute 

 

Dr. Nusbaum is the Scientific Director of the Broad Technology Labs (BTL) and Co-Director of the Genome Sequencing and Analysis Program (GSAP), where he leads single-cell and low-input RNA-seq and associated data analysis.  He has 20 years of experience leading projects in genomics, genome analysis, DNA sequencing and technology development.

He received his Ph.D. at MIT, completed post-doctoral training at UC Berkeley and worked in the biotech industry before joining the Whitehead Institute/MIT Center for Genome Research in 1996 (which became part of the Broad Institute in 2004).

Nigrovic Headshot 2016 12 Final

Associate Director: Peter A. Nigrovic, M.D.

Harvard Catalyst Profile

BRI Profile

Dr. Nigrovic is an adult and pediatric rheumatologist at the Brigham and Women’s Hospital and Boston Children’s Hospital, directing arthritis biorepositories at both institutions. He founded and directs the Center for Adults with Pediatric Rheumatic Illness (CAPRI) at the Brigham and Women’s Hospital.  He is an Associate Professor of Medicine at Harvard Medical School.  Dr. Nigrovic serves on the editorial board of Arthritis & Rheumatology and on the Steering Committee of the US/Canadian pediatric research collaborative CARRA (the Childhood Arthritis & Rheumatology Research Alliance), as well as on the scientific advisory boards of the Rheumatology Research Foundation and the Arthritis National Research Foundation. He is the founding co-chair of AMIGO, the American College of Rheumatology’s inter-institutional mentoring program in pediatric rheumatology.  Dr.  Nigrovic’s research focuses on understanding mechanisms of inflammatory arthritis, using both human samples and mouse models.

Dr. Nigrovic received his Bachelor’s of Arts from Amherst College and his medical degree at Harvard Medical School.  He completed med/peds residency in the Harvard combined program and med/peds rheumatology fellowship at Boston Children’s Hospital and the Brigham and Women’s Hospital.