JBC members research the pathogenesis, outcomes, and treatment of both inflammatory and non-inflammatory arthritis. Obtaining fresh, carefully phenotyped human samples is the most daunting logistical hurdle facing arthritis researchers.
The JBC overcomes this barrier with a systems solution that integrates a novel bioinformatic infrastructure together with an expanded network of personnel to support study design, patient recruitment, data management, and statistical analysis in the Human Biosamples Core. The JBC utilizes an extraordinary range of patient samples, both archived and available through targeted real-time recruitment; core leadership with expertise in cutting-edge bioinformatics and biostatistics; pediatric and adult sources; access to healthy controls as well as patients with comparator diseases; and an established sample processing facility, the Brigham and Women’s Hospital Human Immunology Center.
Mastering new technologies can often be overwhelming, and sometimes requires reaching out to fellow researchers for help. The JBC offers a one stop shop for three technologies for its members in the Cellular Systems Core, which includes HoxB8 cell manipulation for murine samples, CyTOF, and RNA sequencing for both murine and human samples. The JBC not only offers these services cost effectively and hassle free, but also allows investigators access to data analytics, study design, data management, and programming resources for a nominal cost.